A2M
(alpha-2-macroglobulin)

Stop the Progressive Degeneration Due to Arthritis & Inflammation
A2M, Alpha 2 Macroglobulin is a natural inhibitor produced by the liver. This molecule protects cartilage from proteins known to cause degeneration in joints which leads to osteoarthritis. A2M molecules are naturally and evenly found throughout the body. Unfortunately, they are not naturally concentrated in the joints to prevent arthritis. We can concentrate A2M and inject it directly into your affected joints, the A2M concentrate can stop the progression of arthritis.
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A2M halts the progression of osteoarthritis (OA) at the molecular level by inactivating the chemicals that cause the joints to breakdown. A2M’s chief responsibility is to combat other harmful chemicals, proteins, and enzymes that can cause inflammation and tissue erosion when present in large quantities around the joints. The joint will then begin to recover as the inflammation is reduced and harmful chemicals are no longer present. The A2M remaining in the joint will promote tissue growth and the restoration process. The repaired damage will then lead to significant reduction in pain and improved joint function.
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A blood draw is performed where 60mL is collected. The blood is spun down to separate all of the red blood cells and platelets from the plasma. The plasma is then filtered through a hemaconcentrator where the final product will be about 4-6mL of a concentrated A2M product.
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Ultrasound imaging or fluoroscopy is used to guide the injection.
In most patients, concentrated A2M shows promise in reducing pain and improving the damage arthritis causes. Catching arthritis early before destruction has progressed is key for successful treatment. Concentrated A2M injections can still be effective for patients with untreated arthritis. The restoration process may not be as robust, but it will still inhibit further disease progression and can be a great alternative to surgery.